We talk about permanent impairments when the condition of someone will not change in the future. For instance, someone has lost their eyesight due to an eye condition and cannot see a screen at all. Or someone has an eye condition like glaucoma, which causes them to only see parts of the screen. Someone can have a motor impairment, which limits their ability to interact with a mouse and keyboard. But their can also be cognitive permanent impairments, like autism, which causes someone to interact with a website differently.